DMD #7914 Evaluation of the Utility of Brain Slice Methods to Study Brain Penetration
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Evaluation of the utility of brain slice methods to study brain penetration.
The objective of this study was to evaluate the utility of brain tissue slices to determine the effect of plasma and brain tissue nonspecific binding on the brain-to-plasma ratio (K(p)). Mouse or rat brain slices (400 microm) were prepared using a McIlwain tissue chopper (Surrey, UK) and incubated with 1 microg/ml of compound at 37 degrees C either in a physiological buffer to determine the buf...
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تاریخ انتشار 2006